%0 Journal Article
%T Structure of the UHRF1 Tandem Tudor Domain Bound to a Methylated Non-histone Protein, LIG1, Reveals Rules for Binding and Regulation
%J -
%D 2019
%R https://doi.org/10.1016/j.str.2018.11.012
%X £¿ The crystal structure of UHRF1 TTD domain bound to the LIG1K126me3 was determined £¿ Arg121 of LIG1 is a key residue for high-affinity binding to the TTD £¿ Phosphorylation of LIG1T123 negatively regulates the interaction with UHRF1 £¿ LIG1K126me3 binding changes UHRF1 structure from closed to ope
%U https://www.cell.com/structure/fulltext/S0969-2126(18)30455-6