Inhibiting Glutamine-Dependent mTORC1 Activation Ameliorates Liver Cancers Driven by β-Catenin Mutations

？ mTORC1 activation is seen basally in pericentral hepatocytes because of Wnt/β-catenin ？ CTNNB1-mutated liver tumors are positive for GS and p-mTOR-S2448 ？ CTNNB1-mutated hepatocellular cancers are addicted to mTORC1 for metabolism ？ Targeting β-catenin-GS-mTORC1 axis in liver tumors may enable precision medicin