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- 2019
Affinity Improvement of a Cancer-Targeted Antibody through Alanine-Induced Adjustment of Antigen-Antibody InterfaceDOI: https://doi.org/10.1016/j.str.2018.11.002 Abstract: ？ Two Ala substitutions of B5209B considerably improve the antigen-binding affinity ？ One Ala substitution results in enthalpic gain by stabilizing salt bridges ？ The other substitution results in entropic gain by releasing water molecule
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