%0 Journal Article
%T Affinity Improvement of a Cancer-Targeted Antibody through Alanine-Induced Adjustment of Antigen-Antibody Interface
%J -
%D 2019
%R https://doi.org/10.1016/j.str.2018.11.002
%X £¿ Two Ala substitutions of B5209B considerably improve the antigen-binding affinity £¿ One Ala substitution results in enthalpic gain by stabilizing salt bridges £¿ The other substitution results in entropic gain by releasing water molecule
%U https://www.cell.com/structure/fulltext/S0969-2126(18)30421-0