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- 2019
The Histone Methyltransferase SETDB1 Controls T Helper Cell Lineage Integrity by Repressing Endogenous RetrovirusesDOI: https://doi.org/10.1016/j.immuni.2019.01.003 Abstract: ？ Setdb1 ？/？ naive CD4 + T cells have exacerbated Th1 priming and unstable Th2 commitment ？ In Th2 cells, SETDB1 deposits the repressive H3K9me3 mark at a limited set of ERVs ？ In Th2 cells, the ERVs marked by H3K9me3 behave as Th1 gene cis-regulatory modules ？ SETDB1 ensures Th2 cell stability by repressing ERVs that control the Th1 gene networ
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