%0 Journal Article
%T The Histone Methyltransferase SETDB1 Controls T Helper Cell Lineage Integrity by Repressing Endogenous Retroviruses
%J -
%D 2019
%R https://doi.org/10.1016/j.immuni.2019.01.003
%X £¿ Setdb1 £¿/£¿ naive CD4 + T cells have exacerbated Th1 priming and unstable Th2 commitment £¿ In Th2 cells, SETDB1 deposits the repressive H3K9me3 mark at a limited set of ERVs £¿ In Th2 cells, the ERVs marked by H3K9me3 behave as Th1 gene cis-regulatory modules £¿ SETDB1 ensures Th2 cell stability by repressing ERVs that control the Th1 gene networ
%U https://www.cell.com/immunity/fulltext/S1074-7613(19)30003-2