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- 2019
Prion Protein Antagonists Rescue Alzheimer’s Amyloid-β-Related Cognitive DeficitsDOI: https://doi.org/10.1016/j.molmed.2019.01.001 Abstract: Recent studies revealed that cellular prion protein on neurons bind Alzheimer’s amyloid-β oligomers, causing neurotoxic effects. A new article in Cell Reports by Gunther and colleagues ( Cell Rep. 2019; 26:145–158) shows that an orally administered cellular prion protein antagonist can rescue synaptic and cognitive deficits in Alzheimer’s mice overexpressing amyloid-β
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