%0 Journal Article
%T Prion Protein Antagonists Rescue Alzheimer¡¯s Amyloid-¦Â-Related Cognitive Deficits
%J -
%D 2019
%R https://doi.org/10.1016/j.molmed.2019.01.001
%X Recent studies revealed that cellular prion protein on neurons bind Alzheimer¡¯s amyloid-¦Â oligomers, causing neurotoxic effects. A new article in Cell Reports by Gunther and colleagues ( Cell Rep. 2019; 26:145¨C158) shows that an orally administered cellular prion protein antagonist can rescue synaptic and cognitive deficits in Alzheimer¡¯s mice overexpressing amyloid-¦Â
%U https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(19)30003-6