Structure of Calcarisporiella thermophila Hsp104 Disaggregase that Antagonizes Diverse Proteotoxic Misfolding Events

？ The dynamic assembly shows varying tunnel width, helical rise, and domain orientation ？ The N-terminal domain and C-terminal tail are not required for CtHsp104 hexamerization ？ CtHsp104 rescues TDP-43, polyGlu and α-Syn toxicity in yeast and is well tolerated ？ CtHsp104 confers thermotolerance to yeast suggesting collaboration with Hsp70/Hsp4