Viral DNA Binding to NLRC3, an Inhibitory Nucleic Acid Sensor, Unleashes STING, a Cyclic Dinucleotide Receptor that Activates Type I Interferon

？ NLRC3 binds to herpes simplex virus dsDNA via the LRR domain with high affinity ？ DNA binding to NLRC3 diminishes its interaction with STING and TBK1 to enhance IFN-I ？ DNA binding to NLRC3 enhances ATPase activity ？ The ATPase activity of NLRC3 is crucial for DNA-mediated dissociation of STIN