%0 Journal Article
%T Viral DNA Binding to NLRC3, an Inhibitory Nucleic Acid Sensor, Unleashes STING, a Cyclic Dinucleotide Receptor that Activates Type I Interferon
%J -
%D 2019
%R https://doi.org/10.1016/j.immuni.2019.02.009
%X £¿ NLRC3 binds to herpes simplex virus dsDNA via the LRR domain with high affinity £¿ DNA binding to NLRC3 diminishes its interaction with STING and TBK1 to enhance IFN-I £¿ DNA binding to NLRC3 enhances ATPase activity £¿ The ATPase activity of NLRC3 is crucial for DNA-mediated dissociation of STIN
%U https://www.cell.com/immunity/fulltext/S1074-7613(19)30075-5