TNFα-Driven Astrocyte Purinergic Signaling during Epileptogenesis

The etiology of temporal lobe epilepsy is unclear, but proinflammatory molecules and disturbed neuron–glia communications are emerging as potential causers. A recent study (Nikolic et al. Glia 2018; https://doi.org/10.1002/glia.23519) revealed that pathologically elevated tumor necrosis factor α contributes to epileptogenesis, by boosting hyperexcitation through an autocrine mechanism involving purinergic signaling, astrocyte glutamate release, and modulation of neuronal transmitter release