%0 Journal Article
%T TNF¦Á-Driven Astrocyte Purinergic Signaling during Epileptogenesis
%J -
%D 2019
%R https://doi.org/10.1016/j.molmed.2018.12.001
%X The etiology of temporal lobe epilepsy is unclear, but proinflammatory molecules and disturbed neuron¨Cglia communications are emerging as potential causers. A recent study (Nikolic et al. Glia 2018; https://doi.org/10.1002/glia.23519) revealed that pathologically elevated tumor necrosis factor ¦Á contributes to epileptogenesis, by boosting hyperexcitation through an autocrine mechanism involving purinergic signaling, astrocyte glutamate release, and modulation of neuronal transmitter release
%U https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(18)30225-9