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- 2019
Cheating Death: New Molecules Block BAXDOI: https://doi.org/10.1016/j.molmed.2019.02.008 Abstract: BAX is a formidable BCL-2 family protein that executes cellular suicide in response to physiologic and pathologic stress. A new article in Nature Chemical Biology (Garner et al. https://doi.org/10.1038/s41589-018-0223-0) reports small molecules that inhibit the conformational activation of BAX, informing a pharmacologic approach to blocking unwanted cell death in human disease
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