Maturation and Clearance of Autophagosomes in Neurons Depends on a Specific Cysteine Protease Isoform, ATG-4.2

？ Retrograde transport of autophagic vacuoles requires the motor adaptor UNC-16/JIP3 ？ Protease ATG-4.2, but not related ATG-4.1, is required for autophagosome maturation ？ ATG-4.2 cleaves LGG-1/Atg8 to remove it from membranes and enable lysosomal fusion ？ Transport and maturation mechanisms interact to clear autophagosomes from synapse