Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes

？ Single-cell RNA-seq stratifies patients with similar clinical presentation ？ A pseudotemporal profile aligns single cells along a control to disease axis ？ HDAC4 is mislocalized to the nucleus in PD patient iPSC-derived dopamine neurons ？ Repurposed compounds correct HDAC4 mislocalization and revert PD-related phenotype