Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment

？ αS impacts lipid homeostasis, triggering excess oleic acid (OA) and diglycerides (DG) ？ Triglycerides and lipid droplets protect against toxicity by sequestering OA and DG ？ Stearoyl-CoA desaturase (SCD) inhibition rescues αS toxicity and neuron degeneration ？ SCD inhibition decreases αS inclusions and increases αS multimerization and solubilit