%0 Journal Article
%T Lipidomic Analysis of ¦Á-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment
%J -
%D 2019
%R https://doi.org/10.1016/j.molcel.2018.11.028
%X £¿ ¦ÁS impacts lipid homeostasis, triggering excess oleic acid (OA) and diglycerides (DG) £¿ Triglycerides and lipid droplets protect against toxicity by sequestering OA and DG £¿ Stearoyl-CoA desaturase (SCD) inhibition rescues ¦ÁS toxicity and neuron degeneration £¿ SCD inhibition decreases ¦ÁS inclusions and increases ¦ÁS multimerization and solubilit
%U https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30998-5