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- 2019
Protein Kinase C Quality Control by Phosphatase PHLPP1 Unveils Loss-of-Function Mechanism in CancerDOI: https://doi.org/10.1016/j.molcel.2019.02.018 Abstract: ？ Phosphorylation of newly synthesized PKC is necessary for stabilizing autoinhibition ？ PHLPP1 dephosphorylates newly synthesized PKC to provide quality control ？ PKC quality control is conserved in >5,000 patient samples from 19 cancers ？ Pancreatic cancer patients with high PKC and low PHLPP1 have improved surviva
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