%0 Journal Article
%T Protein Kinase C Quality Control by Phosphatase PHLPP1 Unveils Loss-of-Function Mechanism in Cancer
%J -
%D 2019
%R https://doi.org/10.1016/j.molcel.2019.02.018
%X £¿ Phosphorylation of newly synthesized PKC is necessary for stabilizing autoinhibition £¿ PHLPP1 dephosphorylates newly synthesized PKC to provide quality control £¿ PKC quality control is conserved in >5,000 patient samples from 19 cancers £¿ Pancreatic cancer patients with high PKC and low PHLPP1 have improved surviva
%U https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30108-X