Defying Death: The (W)hole Truth about the Fate of GSDMD Pores

Pyroptosis is an inflammatory cell death response initiated by supramolecular organizing centers known as inflammasomes. In a recent issue of Science, Rühl et al. (2018) Rühl S. Shkarina K. Demarco B. Heilig R. Santos J.C. Broz P. ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation. Science. 2018; 362 : 956-960 Crossref PubMed Scopus (2) Google Scholar challenge the paradigm that inflammasome signaling necessitates pyroptosis by demonstrating that ESCRTIII-dependent membrane repair can delay or prevent gasdermin D-mediated cell death