%0 Journal Article
%T Defying Death: The (W)hole Truth about the Fate of GSDMD Pores
%J -
%D 2019
%R https://doi.org/10.1016/j.immuni.2018.12.032
%X Pyroptosis is an inflammatory cell death response initiated by supramolecular organizing centers known as inflammasomes. In a recent issue of Science, R¨¹hl et al. (2018) R¨¹hl S. Shkarina K. Demarco B. Heilig R. Santos J.C. Broz P. ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation. Science. 2018; 362 : 956-960 Crossref PubMed Scopus (2) Google Scholar challenge the paradigm that inflammasome signaling necessitates pyroptosis by demonstrating that ESCRTIII-dependent membrane repair can delay or prevent gasdermin D-mediated cell death
%U https://www.cell.com/immunity/fulltext/S1074-7613(18)30580-6