RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43

？ optoTDP43 is a light-inducible model of TDP-43 proteinopathy and is neurotoxic ？ RNA binding antagonizes aberrant liquid-liquid phase separation (LLPS) of TDP-43 ？ Acute recruitment to RNA-containing stress granules maintains TDP-43 solubility ？ TDP-43 targeting oligonucleotides prevent aberrant LLPS and rescues neurotoxicit