%0 Journal Article
%T RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43
%J -
%D 2019
%R https://doi.org/10.1016/j.neuron.2019.01.048
%X £¿ optoTDP43 is a light-inducible model of TDP-43 proteinopathy and is neurotoxic £¿ RNA binding antagonizes aberrant liquid-liquid phase separation (LLPS) of TDP-43 £¿ Acute recruitment to RNA-containing stress granules maintains TDP-43 solubility £¿ TDP-43 targeting oligonucleotides prevent aberrant LLPS and rescues neurotoxicit
%U https://www.cell.com/neuron/fulltext/S0896-6273(19)30075-3