DNA Damage Signaling-Induced Cancer Cell Reprogramming as a Driver of Tumor Relapse

？ DDR signaling induces DNA demethylation at defined loci, including OCT4 and NANOG ？ macroH2A counterbalances a DDR-signaling-induced activation of OCT4 ？ MYC and SOX2 cooperate with DDR signaling to activate OCT4 transcription ？ OCT4 reactivation contributes to cancer drug resistance and tumor relaps