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-  2019 

Cut-and-Run: A Distinct Mechanism by which V(D)J Recombination Causes Genome Instability

DOI: https://doi.org/10.1016/j.molcel.2019.02.025

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Abstract:

? A complex between the recombination by-product and RAGs triggers multiple DNA breaks ? The breaks co-localize with chromosome breakpoints in acute lymphoblastic leukemias ? The breaks occur at many frequently mutated genes in acute lymphoblastic leukemia ? Cut-and-run may underpin the most common types of lymphocyte chromosome instabilitie

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