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- 2019
MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during MitosisDOI: https://doi.org/10.1016/j.molcel.2019.02.014 Abstract: ？ MDC1 recruits TOPBP1 to DNA double-strand breaks specifically in mitosis ？ MDC1, when phosphorylated on S168 and S196, directly binds TOPBP1 BRCT domains 1 and 2 ？ Loss of MDC1-TOPBP1 binding causes mitotic radiosensitivity and genome instability ？ TOPBP1 forms filamentous assemblies that can bridge MDC1 foci in mitosi
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