%0 Journal Article
%T MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis
%J -
%D 2019
%R https://doi.org/10.1016/j.molcel.2019.02.014
%X £¿ MDC1 recruits TOPBP1 to DNA double-strand breaks specifically in mitosis £¿ MDC1, when phosphorylated on S168 and S196, directly binds TOPBP1 BRCT domains 1 and 2 £¿ Loss of MDC1-TOPBP1 binding causes mitotic radiosensitivity and genome instability £¿ TOPBP1 forms filamentous assemblies that can bridge MDC1 foci in mitosi
%U https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30104-2