MST1 Negatively Regulates TNFα-Induced NF-κB Signaling through Modulating LUBAC Activity

？ TNFα induces the recruitment of MST1 to the TNFR1 signaling complex (TNF-RSC) ？ TRAF2 is required for the TNFα-induced activation of MST1 within the TNF-RSC ？ MST1 phosphorylates HOIP in TNF-RSC, thereby inhibiting an E3 ligase activity of LUBAC ？ MST1 attenuates the LUBAC-mediated activation of the NF-κB pathwa