PINK1 Inhibits Local Protein Synthesis to Limit Transmission of Deleterious Mitochondrial DNA Mutations

？ PINK1 is stabilized on defective mitochondria harboring damaging mtDNA mutations ？ PINK1 phosphorylates Larp to inhibit local protein synthesis on the outer membrane ？ Defective mitochondria become starved of nuclear-encoded mtDNA replication factors ？ Lack of replication limits the transmission of damaging mtDNA mutation