%0 Journal Article
%T PINK1 Inhibits Local Protein Synthesis to Limit Transmission of Deleterious Mitochondrial DNA Mutations
%J -
%D 2019
%R https://doi.org/10.1016/j.molcel.2019.01.013
%X £¿ PINK1 is stabilized on defective mitochondria harboring damaging mtDNA mutations £¿ PINK1 phosphorylates Larp to inhibit local protein synthesis on the outer membrane £¿ Defective mitochondria become starved of nuclear-encoded mtDNA replication factors £¿ Lack of replication limits the transmission of damaging mtDNA mutation
%U https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30013-9