MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network

？ Independent of its canonical activities, MDM2 can promote cell death ？ Cytosolic MDM2 causes oxidative stress, DNA damage, and apoptosis ？ Cytosolic MDM2 sequesters NDUFS1 to destabilize CI·CIII assembly and enhance ROS ？ Mitigation of MDM2-induced mitochondrial ROS prevents DNA damage and subsequent apoptosi