Induction of Selenoprotein P mRNA during Hepatitis C Virus Infection Inhibits RIG-I-Mediated Antiviral Immunity

？ SeP, a hepatokine causing insulin resistance, is increased in HCV patients ？ SeP mRNA binds to RIG-I and inhibits RIG-I-mediated type I IFN immune responses ？ The full-length structure of SEPP1 mRNA is required to regulate RIG-I activity ？ Increased serum SeP in chronic hepatitis C patients is associated with DAAs failur