Lysosomes Dare Cells to be Different(iated)

In this issue of Cell Stem Cell, Villegas et al. (2019) Villegas F. Lehalle D. Mayer D. Rittirsch M. Stadler M.B. Zinner M. Olivieri D. Vabres P. Duplomb-Jego L. De Bont E.S.J.M. et al. Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3. Cell Stem Cell. 2019; 24 ( this issue) : 257-270 Abstract Full Text Full Text PDF PubMed Scopus (0) Google Scholar used a genome-wide CRISPR screen to identify ESC pluripotency regulators, which generated insights into how signaling from lysosome enables cells to transcriptionally regulate their metabolism. Further investigation of human genetics identified a human developmental disease arising from a defect in this process