%0 Journal Article
%T Lysosomes Dare Cells to be Different(iated)
%J -
%D 2019
%R https://doi.org/10.1016/j.stem.2019.01.007
%X In this issue of Cell Stem Cell, Villegas et al. (2019) Villegas F. Lehalle D. Mayer D. Rittirsch M. Stadler M.B. Zinner M. Olivieri D. Vabres P. Duplomb-Jego L. De Bont E.S.J.M. et al. Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3. Cell Stem Cell. 2019; 24 ( this issue) : 257-270 Abstract Full Text Full Text PDF PubMed Scopus (0) Google Scholar used a genome-wide CRISPR screen to identify ESC pluripotency regulators, which generated insights into how signaling from lysosome enables cells to transcriptionally regulate their metabolism. Further investigation of human genetics identified a human developmental disease arising from a defect in this process
%U https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(19)30007-4