Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells

？ Tumorigenesis depends on functional OXPHOS ？ OXPHOS-derived ATP is not required for tumor formation ？ DHODH-driven pyrimidine biosynthesis requires CoQ redox-cycling ？ CoQ redox-cycling via OXPHOS drives tumorigenesis through pyrimidine biosynthesi