%0 Journal Article
%T Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells
%J -
%D 2019
%R https://doi.org/10.1016/j.cmet.2018.10.014
%X £¿ Tumorigenesis depends on functional OXPHOS £¿ OXPHOS-derived ATP is not required for tumor formation £¿ DHODH-driven pyrimidine biosynthesis requires CoQ redox-cycling £¿ CoQ redox-cycling via OXPHOS drives tumorigenesis through pyrimidine biosynthesi
%U https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30646-6