Recurrent Loss-of-Function Mutations Reveal Costs to OAS1 Antiviral Activity in Primates

？ Co-expression of primate OAS1/RNase L in yeast reveals functional diversity ？ Common polymorphisms in human and gorilla OAS1 encode reduced 2–5A production ？ Low-activity OAS1 alleles are pervasive in Old and New World monkeys ？ OAS1 enzymatic activity appears completely lost among species of tamarin monkey