Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation

？ AMPK knockout in T cells accelerates acute lymphoblastic leukemia/lymphoma (T-ALL) ？ Oral treatment with phenformin delays T-ALL development in AMPK-dependent manner ？ Oral metformin has no effect, likely because of the lack of cellular uptake by thymocytes ？ Phenformin lowers glycolysis and oxidative metabolism, reducing T-ALL cell viabilit