%0 Journal Article
%T Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation
%J -
%D 2019
%R https://doi.org/10.1016/j.celrep.2019.03.067
%X £¿ AMPK knockout in T cells accelerates acute lymphoblastic leukemia/lymphoma (T-ALL) £¿ Oral treatment with phenformin delays T-ALL development in AMPK-dependent manner £¿ Oral metformin has no effect, likely because of the lack of cellular uptake by thymocytes £¿ Phenformin lowers glycolysis and oxidative metabolism, reducing T-ALL cell viabilit
%U https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30397-3