|
|
- 2019
The Chimpanzee SIV Envelope Trimer: Structure and Deployment as an HIV Vaccine TemplateDOI: https://doi.org/10.1016/j.celrep.2019.04.082 Abstract: ？ A designed chimpanzee SIV Env trimer binds HIV V2-apex bnAbs specifically ？ The trimer (MT145K) is engineered to bind inferred unmutated versions of HIV V2-apex bnAbs ？ The cryo-EM structure of the SIV MT145K trimer closely resembles that of HIV trimers ？ The MT145K SIV trimer induces HIV-specific nAb responses in a favorable animal mode
|
