%0 Journal Article
%T The Chimpanzee SIV Envelope Trimer: Structure and Deployment as an HIV Vaccine Template
%J -
%D 2019
%R https://doi.org/10.1016/j.celrep.2019.04.082
%X £¿ A designed chimpanzee SIV Env trimer binds HIV V2-apex bnAbs specifically £¿ The trimer (MT145K) is engineered to bind inferred unmutated versions of HIV V2-apex bnAbs £¿ The cryo-EM structure of the SIV MT145K trimer closely resembles that of HIV trimers £¿ The MT145K SIV trimer induces HIV-specific nAb responses in a favorable animal mode
%U https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30562-5