Non-syndromic Mitral Valve Dysplasia Mutation Changes the Force Resilience and Interaction of Human Filamin A

？ FLNA-MVD-causing mutation only slightly changes the FLNa structure ？ SMD simulations suggests that in FLNA-MVD cellular force transmission is altered ？ The main binding site for PTPN12 in FLNa is in domain FLNa4 ？ FLNA-MVD-causing mutation interferes the binding of the PTPN1