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- 2019
Defining a Canonical Ligand-Binding Pocket in the Orphan Nuclear Receptor Nurr1DOI: https://doi.org/10.1016/j.str.2018.10.002 Abstract: ？ A previous crystal structure indicated Nurr1 lacks a canonical ligand-binding pocket ？ Solution NMR and HDX-MS uncover a dynamic putative pocket ？ NMR exposes a similar binding epitope for fatty acids and a synthetic Nurr1 agonist ？ MD simulations and HDX-MS implicate pocket expansion after ligand bindin
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