%0 Journal Article
%T Defining a Canonical Ligand-Binding Pocket in the Orphan Nuclear Receptor Nurr1
%J -
%D 2019
%R https://doi.org/10.1016/j.str.2018.10.002
%X £¿ A previous crystal structure indicated Nurr1 lacks a canonical ligand-binding pocket £¿ Solution NMR and HDX-MS uncover a dynamic putative pocket £¿ NMR exposes a similar binding epitope for fatty acids and a synthetic Nurr1 agonist £¿ MD simulations and HDX-MS implicate pocket expansion after ligand bindin
%U https://www.cell.com/structure/fulltext/S0969-2126(18)30363-0