Conformational Changes in the Cytoplasmic Region of KIR3DL1 upon Interaction with SHP-2

？ KIR3DL1 cytoplasmic domain is intrinsically disordered with three distinct segments ？ TFE and SDS enhanced α-helical conformation around the two tyrosines (ITIMs) ？ SHP-2 SH2 domains decrease NMR peaks around the unphosphorylated N-terminal ITIM ？ Bis-phosphorylated ITIMs are more broadly impacted by the tandem SHP-2 SH2 domain