%0 Journal Article
%T Conformational Changes in the Cytoplasmic Region of KIR3DL1 upon Interaction with SHP-2
%J -
%D 2019
%R https://doi.org/10.1016/j.str.2019.01.009
%X £¿ KIR3DL1 cytoplasmic domain is intrinsically disordered with three distinct segments £¿ TFE and SDS enhanced ¦Á-helical conformation around the two tyrosines (ITIMs) £¿ SHP-2 SH2 domains decrease NMR peaks around the unphosphorylated N-terminal ITIM £¿ Bis-phosphorylated ITIMs are more broadly impacted by the tandem SHP-2 SH2 domain
%U https://www.cell.com/structure/fulltext/S0969-2126(19)30009-7