The Septate Junction Protein Tsp2A Restricts Intestinal Stem Cell Activity via Endocytic Regulation of aPKC and Hippo Signaling

？ The assembly of septate junctions (SJs) occurs during ISC-EC differentiation ？ The SJ protein Tsp2A undergoes internalization and mediates aPKC degradation ？ Normal Tsp2A-SJ assembly ensures Hippo signaling to restrict ISC proliferation ？ Defective Tsp2A-SJ assembly causes aPKC accumulation and Yki hyperactivit