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- 2019
Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in Innate ImmunityDOI: https://doi.org/10.1016/j.cell.2019.03.017 Abstract: ？ RIPLET, not TRIM25, is the obligatory ubiquitin E3 ligase for RIG-I ？ RIPLET recognizes pre-assembled RIG-I oligomers on dsRNA and ubiquitinates RIG-I ？ RIPLET can cross-bridge RIG-I filaments formed on longer dsRNA ？ The two binding modes synergize for length dependent dsRNA discrimination by RIG-
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