%0 Journal Article
%T Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in Innate Immunity
%J -
%D 2019
%R https://doi.org/10.1016/j.cell.2019.03.017
%X £¿ RIPLET, not TRIM25, is the obligatory ubiquitin E3 ligase for RIG-I £¿ RIPLET recognizes pre-assembled RIG-I oligomers on dsRNA and ubiquitinates RIG-I £¿ RIPLET can cross-bridge RIG-I filaments formed on longer dsRNA £¿ The two binding modes synergize for length dependent dsRNA discrimination by RIG-
%U https://www.cell.com/cell/fulltext/S0092-8674(19)30279-X